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The factors that lead to depletion of glutathione includes natural ageing process, or the external stressors that include chronic exposure to chemical toxins, cadmium exposure, alcohol use, smoking, pollution, strenuous aerobic activities, dietary factors, ultraviolet (UV) radiation exposure, tissue injury as from burns, ischemia, septic shock, surgery, drugs (such as acetaminophen and adriamycin)

is supported by the Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW, supported by Novo Nordisk Foundation grant (NNF21CC0073729)) and T.J.R