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Patient Experiences and Expectations Patients using GLP-1 receptor agonists often report not only weight loss but also improvements in overall health and quality of life

noted that although gastrointestinal issues have been related to GLP-1 antagonist use, they consider a diagnosis of gastroparesis to be unusual. Hyposalivation Research has found that semaglutide can cause secondary xerostomia, otherwise known as dry mouth (19)

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Chemical synthesis of macrocycles Macrocycles were synthesized by standard Fmoc solid-phase peptide synthesis (SPPS) using a Syro Wave automated peptide synthesizer (Biotage)