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Importantly, while the organic binding of iodine was blocked, the thyroid gland was still able to concentrate iodine, which suggests that the normal thyroid possesses a mechanism for concentrating iodine that does not depend upon its conversion to thyroid hormones [107]

184 But, in a preclinical study on the DMBA-induced rat mammary carcinoma, this enhanced effectiveness of methotrexate was far outweighted by the growth-stimulating effect of 3-day pretreatment with combined insulin/glucose infusions

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Menon, B., Ramalingam, K