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By contrast, all of the nitrogen and oxygen atoms were rapidly fully deuterated

Methyldopa is taken up into the presynaptic terminal, where it undergoes enzymatic conversion by aromatic Lamino acid (DOPA) decarboxylase to form methyldopamine ( panel 1 )

The most serious side effects include gastroparesis (stomach paralysis), bowel obstruction or ileus requiring surgery, intestinal blockage, gallbladder disease, vision loss including NAION (non-arteritic anterior ischemic optic neuropathy and arteritic anterior ischemic optic neuropathy), sudden vision loss or blindness, deep vein thrombosis (blood clots), severe malnutrition, and organ damage from prolonged gastrointestinal injuries

adults are obese, source: 3 4 5