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In addition, interventions targeting lactylation-associated enzymes, such as the p300 inhibitor C646, might be emerging as promising therapeutic strategies for regulating lactylation (Table 3)

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1,3 A 2025 systematic review in the International Journal of Dermatology confirmed that among GLP-1 receptor agonists, semaglutide and tirzepatide showed the highest reported incidence of hair loss, with telogen effluvium and androgenetic alopecia (AGA) identified as the predominant subtypes

Peptides are targeted biological signals, not supplements