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Weight reduction occurred consistently across different dose levels, with many participants experiencing clinically meaningful improvements in cardiovascular risk factors, including blood pressure and cholesterol levels

Any haziness warrants concern and likely disposal

In models of heart failure (HF), GLP-1 RAs have been observed to alter energy substrate utilization, alleviate myocardial and endothelial inflammation, mitigate oxidative stress, and antagonize myocardial remodeling [14]