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This medication works by binding to and activating the GLP-1 receptor, a receptor commonly targeted in other treatments of type 2 diabetes

The metabolic benefit isn't automatic

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Average weight loss was ( 7.8 pounds (3.55 kg) for a 3.75/23 mg (phentermine/topiramate) dose 16 pounds (7.27 kg) for a 7.5/46 mg dose 18 pounds (8.25 kg) for a 15/92 mg dose In users of phentermine-topiramate, weight loss translated to a significant decrease in waist circumference as well as improved insulin sensitivity, improved blood sugar management, and reduction in blood pressure ( May be helpful for certain eating disorders The combination of phentermine and topiramate may help reduce binge eating in people with BED and bulimia nervosa