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However, as explained by the Alzheimers Drug Discovery Foundation in 2024, while urolithin A does have an impressive safety profile, its long-term safety has yet to be established.4 Also, while rare, some people can be allergic to pomegranates, which are rich in the polyphenols that are metabolized into urolithin A.21 This doesnt necessarily mean that those with pomegranate allergies will have a reaction to urolithin A supplements, but it could be something to keep in mind

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Important safety considerations: Patients should contact their GP if they experience severe injection site reactions, signs of infection (fever, spreading erythema), chest pain, palpitations, or allergic symptoms

B12 has also been loosely linked to serotonin production, the brain chemical that promotes good moods and wards off depression