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Inhibiting the actions of integrin on the surface of immune cells and endothelial cell adhesion molecules inhibits interaction between leucocytes and intestinal vasculature which blocks the inflammatory process[85]

This hypothesis was supported by results that also OPC differentiation was significantly induced, axons were re-wrapped, and axonal damage was reduced after T4 treatment at the late stage of EAE (day 30 after onset), and that OPC differentiation significantly correlates with the neurological functional score (Zhang et al., 2016a)

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