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Schema-Friendly Fact Summary : Cigarettes release over 7,000 chemicals when burned

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The Lancet , 379 , 13411351

"The high-risk variants increase the risk of cessation failure, and this increased risk can be ameliorated by cessation pharmacotherapy." In other words, those predisposed to nicotine addiction find it the hardest to quit cold turkey, but also respond the best to medications that biologically address that addiction, whereas the genetically fortunate who are least likely to become addicts are also the most likely to be able to quit without any help