why chewing tobacco is harmful for health doesn't damage your overnight. It starts quietly. A pouch here. A chew there. A habit that feels harmless. But long before symptoms appear, tobacco can begin affecting your mouth, heart Chewing tobacco - Wikipedia

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Diet-pharma-cessation-microbe axis mitigates tobacco-driven gut dysbiosis Multimodal interventions encompassing dietary modulation, pharmacotherapy, smoking abstinence, probiotic supplementation, and microbial metabolite administration demonstrate efficacy in counteracting tobacco-induced gut dysbiosis and restoring microbial equilibrium

Role of Oral Microbiota in Cancer Development

Significantly higher abundance of Streptococcus was found to adequately discriminate smokeless-tobacco-non-consuming healthy samples from smokeless-tobacco-consuming healthy samples and contralateral healthy site of OSCC samples from the tumor site of OSCC samples