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Exposure to cigarette smoke induces multiple pathological effects in the endothelium, several of which are the result of oxidative stress initiated by reactive oxygen species, reactive nitrogen species, and other oxidant constituents of cigarette smoke

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In addition, Bacillus showed a positive correlation with benzaldehyde, while Kocuria displayed a positive correlation with 2-acetylfuran, isophorone, 2, 6-nonadienal, and -damascenone

Clinically, this pattern of receptor desensitization may explain the phenomenon where smokers prefer the first cigarette in the morning, and why cognitive deficits are present during periods of withdrawal (106)