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However, a reversal in the down trend is being observed in developed countries 4-7

Smoking remains one of the leading causes of lung cancer, chronic obstructive pulmonary disease, stroke, and cardiovascular disease

Key strengths include the exceptionally large sample size, long follow-up, and detailed adjustment for clinical, behavioral, and socioeconomic confounders, allowing robust assessment of interactions between initiation age and smoking intensity

The neuropsychiatric safety of CHANTIX was evaluated in a randomized, double-blind, active and placebo-controlled study that included patients without a history of psychiatric disorder (non-psychiatric cohort, N=3912) and patients with a history of psychiatric disorder (psychiatric cohort, N=4003)