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Varenicline Trade Names: Chantix, Tyrvaya Drug Class: Nicotinic partial agonist (selective for the 42 subtype) Mechanism of Action: Partial Agonism : Varenicline binds with high affinity and selectivity as a partial agonist to 42 neuronal nicotinic receptors (nAChRs) in the brain (Mihalak et al, 2006

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