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Another study in rats evaluated the neurotoxicant effects of prenatal and adolescent nicotine exposure and found the PNE administration produced cellular alternations including net cell losses in the midbrain, and regional enlargement of the hippocampus [164]

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The findings demonstrate a significant, and larger than previously estimated, contribution of alcohol to death, disability, and ill health, globally. These recent findings should prompt public health agencies around the world to reconsider viewing the alcohol industry as an accepted participant in health policy making