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For F15.20, the Applicable To notes list four terms: Amphetamine type substance use disorder, moderate, Amphetamine type substance use disorder, severe, Other or unspecified stimulant use disorder, moderate, and Other or unspecified stimulant use disorder, severe. This confirms that F15.20 maps to both moderate (4 to 5 criteria) and severe (6 or more criteria) amphetamine-type substance use disorder under DSM-5, as well as other/unspecified stimulant use disorders at both severity levels

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These findings were further supported using concentration-response experiments with BEAS-2B cells in submerged monolayer cultures