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A recent analysis utilizing methods by a 2017 CDC study [17] estimated a total economic cost of the opioid epidemic at $2.7 trillion in 2023, with $1.1 trillion (41%) from opioid overdose deaths, $1.34 trillion (39%) lost in quality of life, and $277 billion (10%) from healthcare costs, labor productivity, and criminal legal system-related costs [18]

To be granted an MRTP, a manufacturer must demonstrate to the FDA that the product will or is expected to benefit the health of the population as a whole. That decision was a significant step in the FDA acknowledging the potential benefits of HTPand of tobacco harm reduction more broadly