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A lower dose of 2.5 mg twice a day is recommended in people with creatinine less than 1.5mg/dL who are 80 years of age or older and have a weight of less than 60kg (132 pounds)

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Although demand by the major trade partners, such as the United States and the EU, is expected to be weaker in the longer term, production is expected to decline in developed countries giving an opportunity for expanding production from Africa

Experts attribute the decline to smoking bans, cigarette taxes and anti-smoking campaigns by both nonprofit groups like the American Cancer Society and the federal government