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Smoking continues to kill millions of people worldwide, despite decades of prevention campaigns, cessation programs, and pharmacological support

We investigated with voltage-clamp experiments, effects of aqueous extracts (coffees) of unroasted and roasted coffee beans on the activity of human brain nicotinic acetylcholine receptor (nAChR) subtypes expressed in Xenopus oocytes, looking at complex brews, low molecular weight (LMW) fractions, and specific compounds present in coffee

Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions

The symptoms people experience if they cut back on nicotine make it incredibly difficult and uncomfortable, painful, to quit, Piper says