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Nicotine is the major addictive substance and primary reinforcer of continued smoking, and there are 72 measurable carcinogens in smoking

Kenneth Warner, a tobacco expert at the University of Michigan's school of public health, called the idea "good in concept," but said he would be "astonished if there's much of a market for this." Reduced-nicotine cigarettes have been around for decades, mostly for research, according to the FDA, while previous efforts to sell low-nicotine products have fallen flat

36 The German Federal Institute for Risk Assessment (BfR) also conducted an independent analysis of THS and found that the levels of major carcinogens are markedly reduced in the emissions of the analysed [heat not burn] product in relation to the conventional tobacco cigarettes, and that monitoring these emissions using standardised machine smoking procedures generates reliable and reproducible data, which provide a useful basis to assess exposure and human health risks. 37 Published research on existing HTPs available in various markets confirms the reduction in the number and levels of HPHCs

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