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Aside from inactivity, smoking causes muscle fatiguability on its own by reducing: blood flow to the muscle (reducing transport of oxygen and nutrients) oxygen binding to hemoglobin/ mitochondrial entry (due to carbon monoxide build up) adenosine triphosphate production by muscle mitochondria muscle mitochondrial structural integrity (increasing production of harmful reactive oxygen species within muscle) Maximal muscle strength : In contrast to muscle fatiguability, the effects of smoking on muscle strength are less clear
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