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Other variables, such as frequency of tooth cleaning and years of tobacco use, were also first examined, but they were not included in the final model as they did not contribute significantly to the model, and their inclusion led to low model stability

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Pope Urban VIII likewise condemned smoking in holy places in a papal bull of 1624

Notably, 14 of the 23 biomarkers of exposure were significantly reduced in adults who switched to e-cigarettes compared to their baseline levels measured when they were smoking cigarettes [43, 44]