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Data from low-SDI regions, in particular, may be less reliable due to limited health infrastructure and reporting systems

The technique is especially appropriate for testing the whole taste sensory chains integrity including ionotropic transduction mechanisms, but excluding metabotropic transduction mechanisms because sweet bitter or umami taste transduction mechanisms rely on second messenger systems and are not activated by EGM stimulation (ionic stimuli) [43]

For practical purposes these are indistinguishable and the products can simply be thought of as having the same low risk, says Phillips, adding that unlike in most areas of harm reduction, these substitutes for the dangerous product are so benign that they can be treated as no more risky than abstinence