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Secret behind nic-sickness could help break tobacco addiction The brain's dopamine network activated by high doses of nicotine could be tweaked to make smoking aversive at lower doses to help people kick the habit August 10, 2022 If you remember your first hit on a cigarette, you know how sickening nicotine can be

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To minimize this potential bias from unmeasured confounding, analyses accounted for baseline differences between cohorts (eg, age), differences among current, former, and never smokers, temporal trends (eg, declining smoking rate, increasing BMI), birth cohort effects, and factors that could influence both smoking cessation and CVD risk, including sociodemographic factors and known CVD risk factors, which were time-updated

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