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Prospective cohort studies make it possible to estimate directly the number of deaths caused by smoking or other factors, but they are expensive to carry out, require decades of commitment, and often are not available for populations one wishes to study

(ii) is supplied to the retailer by the tobacco product manufacturer, importer, or distributor, who has the required state, local, or Alcohol and Tobacco Tax and Trade Bureau (TTB)-issued license or permit, if applicable

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New products, particularly e-cigarettes, work both to entice customers who might not have used a combustible cigarette and re-engage/retain current or former users of traditional tobacco products