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Special populations: Renal impairment: Use with caution in patients with severe renal impairment as the clearance of nicotine and its metabolites may decrease, potentially leading to increased adverse effects

[1] After a period of disagreements with his father, Joel Sherman left the business for about a decade

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There was some evidence that the policy had a detrimental impact on cigarette use among sexual minorities, but the reasons for this finding remain unclear