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Although the etiology of pulmonary hypertension in smokers is not understood, recent work has suggested a role for inducible nitric oxide synthase (iNOS) in inducing oxidative stress, as explained in the study Pulmonary hypertension and vascular oxidative damage in cigarette smoke exposed eNOS(-/-) mice and human smokers, authored by Wright JL, Zhou S, Churg A, from the Department of Pathology, of the University of British Columbia, in Vancouver, Canada

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Again, the subjects were healthy young men with normal blood pressure