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Though vaping exposes the us er to fewer toxic substances than smoking, it is not harmless: the aerosol inhaled and exhaled during vaping may contain nicotine, heavy metals, and carcinogens.Encouragingly the levels of carcinogens and toxins in e-cigarettes are much lower than in cigarettes, and short-term studies suggest that smokers who switch to vaping do experience reduced exposure to carcinogens

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Combination therapy may be beneficial for individuals who have a history of depression or failed to achieve smoking cessation on varenicline monotherapy