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Food and Drug Administration), mainly consisting of products containing synthetic nicotine.) This type of product mainly includes nicotine products consisting of nicotinetypically free nicotine, nicotine salts, or nicotine polacrilexcombined with other ingredients, which themselves may or may not be harmful to health depending on the particular ingredients in question and the route of administration involved

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Casecontrol and cross-sectional studies also predominated, both which are problematic in terms of accounting for bias, such as failing to account for temporality of exposure and outcome, as well as former smoking status, rendering cross-sectional studies inappropriate for causal inferences