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In the World Health Organization (WHO) European Region, the estimated tobacco smoking prevalence in 2015 was 27% 3 and smoking accounts for 25%, 41% and 63% of cardiovascular disease, cancer and respiratory disease deaths in men, and 6%, 10% and 37% of deaths in women, respectively 4

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the only way to reduce the frequency and severity of acute exacerbations of COPD is to relieve the symptoms and thereby improve the quality of life of COPD patients