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Canadian authors of a 2020 meta-analysis of 32 RCTs of drug treatment for major depressive disorder in people with concurrent SUDs concluded that SSRIs either alone or in combination with relapse prevention medications such as naltrexone, had no significant effect on depressive symptoms

Early symptoms of lung disease may include: a chronic cough coughing up mucus for a month or longer coughing up blood wheezing shortness of breath chronic chest pain Its a good idea to contact a doctor if you have any of these symptoms, especially if you smoke

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