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The ARfD for nicotine is 0.0008 mg/kg bodyweight [3]

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Almost five years later, in March 2018, the FDA again requested public comment on the role that menthol in tobacco products plays in attracting youth, in the likelihood of quitting smoking, and in the use of other tobacco products, including cigars and e-cigarettes

There is also some evidence which suggests that smoking may play a role in the onset of mental health conditions