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Signs and symptoms of an overdose of NICOTROL NS would be expected to be the same as those of acute nicotine poisoning including: pallor, cold sweat, nausea, salivation, vomiting, abdominal pain, diarrhea, headache, dizziness, disturbed hearing and vision, tremor, mental confusion, and weakness

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CO hypoxia is not detected by pulse oximetry.5 Tissue hypoxia causes decreased inotropy and increases in cardiac dysrhythmias (with COHb as little as 4-5%), necessitating close electrocardiographic monitoring