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In studies on lab mice, those exposed to e-cigarette smoke had higher levels of DNA damage in the heart, lungs, and bladder, compared with control mice exposed to filtered air, said Similar effects were seen when human lung and bladder cells were exposed to nicotine and nicotine-derived nitrosamine ketone (NNK), a carcinogenic nicotine derivative

This may be thought of as the notional prevalence of smoking (ever vs never) in the UK population more specifically, the prevalence that would have been necessary in the UK population to produce the observed incidence rates if the relative risks of the CPS II study had pertained

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This is because cannabis can change the way the body responds to various medications