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It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

Sinha D.N., Gupta P.C., Kumar A., Bhartiya D., Agarwal N., Sharma S., Singh H., Parascandola M., Mehrotra R

As occurs with many of the elements above, animals can cut themselves on glass or ingest it without being able to digest it

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