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doi: 10.1016/j.scitotenv.2021.152667 42 SoleimaniF.DobaradaranS.MohebbiG.VazirizadehA.De-la-TorreG

The smoke contains the same toxic chemicals as a cigarette and can cause similar harm to our heart

Risk factors for PDAC include tobacco smoking, germline mutations in such genes as breast cancer gene 1 ( BRCA1 ) and BRCA2 , chronic pancreatitis, obesity, long-standing type 2 diabetes (T2DM), and prolonged and excessive alcohol consumption ( While several chemotherapy regimens have been approved for metastatic PDAC, the most widely used and best-studied agent is Gemcitabine, a drug was first approved by the FDA for metastatic PDAC in 1996, after showing marginal efficacy in clinical trials ( Standard of Care Treatment Overview The clinical management of patients with pancreatic cancer varies depending on several factors, ranging from overall health and wellness to the wishes of the patient and family ( Figure 1 )

Epidermal multinucleated keratinocytes: a histopathologic clue to dermatitis artefacta