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The differences in the ln-transformed values of the BoE between study groups (IT2.0a, DT2.2a, THP, THS and SS) and comparator study group (CC) were evaluated using analysis of covariance, with the endpoints observed at the end of exposure (Day 5) by study group and site, with the baseline (Day 1) value as a covariant (two-sided significance level with 5% alpha level, Bonferroni-correction, = 0.05/5)

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The cigarette is like a manufactured cigarette

This depends on two factors: Smoke-free alternatives must have significantly lower risk compared with cigarettes