The American Cancer Society's Cancer Prevention Study II found elevated relative risks (i.e., the risk of the conditions among smokers compared to nonsmokers) for current smoking of 10.9 for males and 5.1 for females for lip, oral cavity, and pharyngeal cancers (i.e., male smokers have 10.9 times higher risk of developing these cancers than male nonsmokers, and female smokers have 5.1 times higher risk of developing these cancers than female nonsmokers) and 14.6 for males and 13.0 for females for laryngeal cancer (Ref
Theres about sixty years of science backing up the fact that smoking is a high risk activity, because usually half of those that smoke in the long term end up dying

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Guidance to Industry On September 12, 2024, FDA issued guidance for industry that describes the agencys enforcement policy for the final rule