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We also present new data showing similar epigenomic changes in the cells of e-cigarette users who had smoked less than 100 tobacco cigarettes in total in their lives, meaning that they are essentially never-smokers

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Genetic risk score (GRS) To determine if known smoking-associated SNPs could explain the ancestry effect, we repeated the ancestry analyses including a GRS for each smoking-related trait based on the findings of the largest genetic study conducted to date, including up to 1.2 million individuals with information on multiple stages of tobacco use 15