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In taking a detailed look at the issue in research published in 2019, the Irish Longitudinal Study on Ageing (TIDLA) was able to distinguish between individuals who may not feel lonely despite a small social network and those who do within a larger social circle

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individuals with polymorphisms in genes encoding the enzymes primarily involved in nicotine metabolism (e.g., cytochrome P-450, family 2, subfamily A, polypeptide 6