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Similarly, proteins in the Starch and sucrose metabolism pathway, such as hexokinase ( HK ) and glucan endo-1,3-beta-d-glucosidase ( EGLC ), were also significantly upregulated ( However, under low-temperature stress, 61 proteins in the Ribosome (map03011) pathway, including Small subunit ribosomal protein S10 (RP-S10), Large subunit ribosomal protein L4e ( RPL4 ), Large subunit ribosomal protein L2 ( MRPL2 ), Large subunit ribosomal protein L14 ( MRPL14 ), and Small subunit ribosomal protein S11 ( rpsK ), were downregulated, indicating that chilling injury caused ribosomal instability in tobacco leaves, thereby inhibiting protein synthesis

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According to the YRBSS (2015), teens aged 15 or 16 are at the highest risk for smoking initiation