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5 The shared genetic vulnerability hypothesis: a helps to identify the direction of the association between smoking and schizophrenia b is strengthened by consistent replication of genetic studies c implicates CHRNA3 , CHRNA4 and CHRNA5 as common genes in the development of nicotine dependence and schizophrenia d implicates the BDNF , DBH , OPRM1 and DRD2 genes in developing resistance against tobacco use in people with schizophrenia e opposes the smoking causes schizophrenia hypothesis