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For the uninitiated in 91, the entry point for new Metallica fans was Enter Sandman. The lead single off of the Black Album opened the door of discovery, not only for the band but for an entire genre

McKay SE, Lafrance D

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In the case of drinks per week , the simulations showed that there is a negligible influence of frailty effects biasing the MR results as the effect induced solely by frailty in the IVW analysis was an OR of 0.994 (95% CI 0.9091.087) compared to the MR result OR of 0.78 (95% CI 0.690.88) (Fig