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These novel non-combustible products are available in tobacco-derived (TDN) and tobacco-free nicotine (TFN) forms, but due to the sparsity of data on toxicity, health effects and increased consumption, these products have become a significant public health concern

In several countries, specific forms of smokeless tobacco use characterized by high concentrations of carcinogens continue to be widely consumed, often involving products that are not authorized or regulated (21)

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