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Doss, Povazan [18] (2) compared the FC effects of Psi with those of the conventional antidepressant escitalopram, and blinded participants by administering a low dose of Psi to the escitalopram group and daily placebo pills to the Psi group to mimic the daily administration of escitalopram

Additionally, presynaptic dopamine released both subcortically and within the frontal regions of the brain are influenced by inhibitory GABA interneurons, therefore disruption in GABA signaling via NMDAR abnormalities has also been linked to abnormalities in dopamine signaling (73, 90, 91)