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Moreover, the covariate selection algorithm identified a significant difference between data points that were maximally controlled and those that were not and a further difference between data points that controlled for age, sex, and smoking, and those that did not control for smoking, so the two corresponding covariates were used to accordingly adjust the observations included (Table 2)

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To identify the initial drug for the line extension, CMS would use information from the Medicaid Drug Program system and identify line extensions based on manufacturer reporting of drugs as line extensions and related pricing and product data in that system

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