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The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling: Adverse reactions commonly reported by COC users are: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to the rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice

Ireland passed a similar law last year and Australia's had plain packaging since 2012

Reviews often describe it as better for smokers who value flavor more than odor control