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doi: 10.1186/s13643-018-0933-0 11

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Risk factors for deficiency include active disease and sulfasalazine or methotrexate treatment.32,33 Erythema nodosum (EN) is characterized by painful erythematousviolaceous subcutaneous plaques or nodules that are usually 15 cm in diameter, often located symmetrically on extensor surfaces of the lower extremities but also on the thighs and forearms