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Covariates All models were adjusted for age, sex, education, socioeconomic status (household income and Townsend deprivation index [23]), body mass index (BMI), physical activity, diet, alcohol consumption, passive smoking, occupational exposure, the relatedness of individuals in the sample and first 20 principal components of ancestry

These individuals had used heroin by chasing the dragon or inhaling the vapors of heroin that had been heated on aluminum foil