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additionally, nicotine-containing e-cigarettes did not decrease forced expiratory flow (FEF) compared with cessation of e-cigarette use (48)

Administration of vape liquid has been shown to upregulate the expression of CYP2A6, CYP2U1, CYP2E1, and CYP2S1 mRNA (162), and exposure to condensed electronic cigarette aerosol induces CYP1A1 and CYP1B1 activity (164)

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